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BTB Domain Database
This database catalogs BTB proteins found in 17 fully sequenced eukaryotic genomes. This database was the source for the analysis presented in the artcile "Sequence and structural analysis of BTB proteins." Stogios PJ, Downs GS, Jauhal J, Nandra S and Privé GG, Genome Biology, 6:R82 (2005)

Protein sequences and annotation information can be retrieved by searching by keywords or protein architecture (searching by gene or protein names, alternate names, or domain content), search by BTB ID (each gene encoding a protein with a BTB domain was given a unique identifier), search by sequence (query sequence is matched with our database via BLAST), or search our family of BTB-specific HMM's (to identify which subfamily your BTB domain falls under).

More information on database construction information here.

Search by keywords or protein architecture

Search keyword(s):
Select fields to search:
       Protein name and aliases
       Ensembl gene ID
       Uniprot ID
       RefSeq ID

Search species:

Search BTB protein architecture:

Logical operator between domains (use Ctrl/Apple key to select multiple domains):

 Show all proteins in database

Search by BTB ID

Search BTB IDs:

Example queries: 5,304-732,76,34,2401-2403

Change fields to display with your search

 Show all fields

 Name and Aliases          Ensembl Gene ID
 Ensembl Transcript ID    Ensembl Peptide ID
 Uniprot ID                      RefSeq ID

Domain Architecture
 Show HMM info for BTB domain: e-value, BTB start+end sites
      ( HMM definitions )
 Show partner (non-BTB) domains

( FASTA definitions )
 Uniprot/Ensembl definition        Short FASTA definition
 Named FASTA definition

 Full protein length           Full protein sequence
 BTB domain sequence
 Sequence N-terminal to BTB domain
 Sequence C-terminal to BTB domain

Sort by:

Splice Variants
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Search by sequence

Enter a query sequence, will be BLASTed against BTB database:

Species to BLAST:    Expect value cutoff:
Filter low-complexity sequence with SEG: Yes    No
Other BLAST parameters set as their defaults at NCBI.

Search against BTB family-specific HMMs (uses hmmpfam command from HMMER package, useful for locating and classifying a BTB domain into a subfamily)

Enter a query sequence, will be searched against all BTB family-specific HMMs:

This page last updated: September 13, 2007
Webmaster: Peter Stogios